Considering the sensitivity of TRPA1 to aldehydes and the cross-talk between TRPA1 and TRPV1 — this is an important study in relation to the discussion of TRPV, insulin and adrenaline.
Marchitti, S. A., Deitrich, R. A., and Vasiliou, V. (2007). Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: The role of aldehyde dehydrogenase. Pharmacol Rev, 59(2):125-150.
http://www.citeulike.org/user/HEIRS/article/3272780
“Aldehydes are highly reactive molecules formed during the biotransformation of numerous endogenous and exogenous compounds, including biogenic amines. 3,4-Dihydroxyphenylacetaldehyde is the aldehyde metabolite of dopamine, and 3,4-dihydroxyphenylglycolaldehyde is the aldehyde metabolite of both norepinephrine and epinephrine. There is an increasing body of evidence suggesting that these compounds are neurotoxic, and it has been recently hypothesized that neurodegenerative disorders may be associated with increased levels of these biogenic aldehydes. Aldehyde dehydrogenases are a group of NAD(P)+-dependent enzymes that catalyze the oxidation of aldehydes, such as those derived from catecholamines, to their corresponding carboxylic acids……read more
Filed under: environmental illness | Tagged: adrenaline, aldehydes, environmental illness, epinephrine, neurotoxicity, TRPA1, TRPV1, update
