Environmental exposures from chemicals, molds, etc. reduce antioxidant stores not just in cells in the respiratory tract or the point of contact but also systemically. Antioxidants are an important part of the detoxification system. Their reduction causes tissue damage through the action of reactive species and subsequently an increase in the growth of “bad” intestinal bacterial causing further reductions in antioxidant stores and decreased nutritional absorption through the loss of “good” bacteria and inflammation. “Bad” bacteria speed up the process of lipid peroxidation causing more epithelial damage and irritation and change the natural environment of the intestines. Unfortunately, symptoms of MCS can increase from the excretion of volatiles from “bad” bacteria including aldehydes and hydrogen sulfide into the intestinal tract. The release of substance P, a pain neurotransmitter, activation of nociceptors, alterations in cell signaling, and generation of more reactive species are all the result of epithelial tissue damage and lead to damages to nerves and to cellular organelles that drive cellular functions such as the endoplasmic reticulum responsible for protein synthesis and the mitochondria which produce energy.
Recommended Resource: http://www.scribd.com/doc/3941505/Food-and-Nutritional-Toxicology
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Kimberly Kramer
Health Educator and Researcher
Health Education Information and Resource Services
kkramer@heirs-online.com
http://www.heirs-online.com
Filed under: Biological Pathways, Cell Biology, Crohn's Disease, Enzymes, Fibromyalgia, Food Intolerance, Hormones, Chemicals Signals, Neurotransmitters, etc., Inflammatory Bowel Disease, Irritable Bowel Syndrome, Medical Conditions, Mitochondrial Dysfunction, Multiple Chemical Sensitivity, Nociception, Nutrition & Diet, Oxidative Stress, Receptors, Substance P, TRPV1, Ulcerative Colitis, environmental illness, pain management | Tagged: aldehydes, altered intestinal flora, antioxidants, endoplasmic reticulum stress, environmental exposures, hydrogen sulfide, MCS, mitochondria, multiple chemical sensitivity, nociceptors, oxidants, pathogenic bacteria, probiotics, substance P, TRPA1, TRPV1
