HEIRS Research: Another Great Schematic of Nrf2 W/ Assoc Interactions of Proteins

We wanted to make sure we posted a great scematic and a great article that helps to explain how different food chemicals interact with proteins to initiate gene responses. We have been discussing this for quite awhile now and hopefully you have a good basic background of information about phytochemicals and their actions on cellular pathways. The following is a great article to add to that arsenal of information that will help you (the audience) to understand why food is so important to Nrf2 and to other important promoters of gene regulation and their relationship to environmental illnesses.

The Schematic – Figure 1 - showing Nrf2, FoxO and SIRT1. All of these we discuss in the “Gist of Environmental Illness“.  When looking at this diagram try to ignore most of the arrows for now. What is most important is to note how all of these interact – 1)that one action can effect the action of another 2) catechins have an impact on PKC 3) sulphoraphane impacts the bonds between keap and Nrf2 4) garlic activates the ion channel (TRP)  5) resveratrol acts on SIRT1. 

Notes

• Nrf2 activates the ARE (antioxidant response element) that provides numerous protective benefits because it mediates antioxidant proteins. Chen has shown through his study that Nrf2/ARE also can suppress redox-sensitive inflammatory genes. (Chen)
• You also might note that this schematic  shows much of the action is directed through PI3K. A signaller that we have discussed many times in our posts.

Viewpoint: Mechanisms of Action and Therapeutic Potential of Neurohormetic Phytochemicals.

For Further Reading: (Note the search field on heirsonline blog for WordPress does not always work)

• HEIRS Abstracts: Nrf2, phytochemicals, phytonutrients, nutrition, IGF-1

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Mattson, M. P., Son, T. G., and Camandola, S. (2007). Viewpoint: mechanisms of action and therapeutic potential of neurohormetic phytochemicals. Dose-response : a publication of International Hormesis Society, 5(3):174-186. http://www.citeulike.org/user/HEIRS/article/3812627

Chen, X.-L., Dodd, G., Thomas, S., Zhang, X., Wasserman, M. A., Rovin, B. H., and Kunsch, C. (2006). Activation of nrf2/are pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression. Am J Physiol Heart Circ Physiol, 290(5):H1862-1870. http://www.citeulike.org/user/HEIRS/article/3578531

Macpherson, L. J., Geierstanger, B. H., Viswanath, V., Bandell, M., Eid, S. R., Hwang, S., and Patapoutian, A. (2005). The pungency of garlic: activation of trpa1 and trpv1 in response to allicin. Current biology : CB, 15(10):929-934. http://www.citeulike.org/user/HEIRS/article/3857450